Variations in initial renal transplant function by type of organ retrieval

Transplant Proc. 2013;45(10):3603-5. doi: 10.1016/j.transproceed.2013.09.016.

Abstract

Background: Numerous factors have been associated with early delay in kidney function and thence the graft survival. However, few data are derived from different types of donation: single or multiorgan. Our goal was to analyze the association of type of retrieval with the early function of the renal graft.

Methods: A retrospective analysis of transplantations performed in the Reina Sofia Hospital from January 2004 to June 2012 from local deceased donors was carried out. We performed a descriptive analysis of the variables and univariate and multivariate analyses with the use of logistic regression to determine the association of type of retrieval (kidney-only [KO], kidney-liver [KL], and multiorgan [MO]) with delayed graft function (DGF) and early graft failure (EGF).

Results: We analyzed 287 kidney transplantations from 182 deceased donors, of which 25 (13.7%) were KO, 80 (43.9%) KL, and 77 (42.3%) MO. DGF was higher in MO retrievals compared with KL and KO (25.8% vs 24% vs 20.5%), though without reaching significance (P = .81). EGF at 3 months was 17.6% in KO compared with 10.5% in KL and 5.3% in MO (P = .2). Regarding DGF, in the multivariate analysis, donor age (P = .049) and donor sex (P = .029) appeared to be related to DGF. There were no differences by type of retrieval. Multivariate logistic regression analysis established a significant relationship between KO retrieval and EGF at 3 months (P = .005) compared with MO.

Conclusions: Early graft function at 3 months decreases when the allograft is from KO retrievals compared with MO, probably related to the more unfavorable characteristics of these donors and their corresponding recipients.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Chi-Square Distribution
  • Delayed Graft Function / etiology
  • Delayed Graft Function / physiopathology
  • Female
  • Graft Survival
  • Humans
  • Kidney / physiopathology
  • Kidney / surgery*
  • Kidney Transplantation / adverse effects
  • Kidney Transplantation / methods*
  • Liver Transplantation
  • Logistic Models
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Nephrectomy / adverse effects
  • Nephrectomy / methods*
  • Retrospective Studies
  • Risk Factors
  • Spain
  • Time Factors
  • Tissue and Organ Harvesting / adverse effects
  • Tissue and Organ Harvesting / methods*
  • Treatment Outcome