Autophagy-mediated tumor promotion

Cell. 2013 Dec 5;155(6):1216-9. doi: 10.1016/j.cell.2013.11.019.

Abstract

Mouse models for cancer are revealing novel cancer-promoting roles for autophagy. Autophagy promotes tumor growth by suppressing the p53 response, maintaining mitochondrial function, sustaining metabolic homeostasis and survival in stress, and preventing diversion of tumor progression to benign oncocytomas.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Autophagy*
  • Carcinogenesis*
  • Humans
  • Neoplasms / metabolism*
  • Neoplasms / pathology
  • Tumor Suppressor Protein p53 / metabolism
  • ras Proteins / metabolism

Substances

  • Tumor Suppressor Protein p53
  • ras Proteins