Oncolytic vaccinia virus in combination with radiation shows synergistic antitumor efficacy in pancreatic cancer

Cancer Lett. 2014 Mar 28;344(2):282-90. doi: 10.1016/j.canlet.2013.11.007. Epub 2013 Dec 7.

Abstract

Combining oncolytic viruses with conventional therapy such as radiation is an innovative option for pancreatic cancer. We demonstrated that combination of GLV-1h151 and radiation yielded a synergistic cytotoxic effect, with the greatest effect achieved in the AsPC-1cell line. Combination treatment significantly increased apoptosis compared with either single treatment or the control group. In mice bearing human pancreatic tumor xenografts, combination treatment resulted in significantly enhanced inhibition of tumor growth. No evidence of toxicity was observed in mice. These results indicate that the combination of GLV-1h151 and radiation has great potential for translation into clinic practice.

Keywords: Pancreatic cancer; Synergism; Virus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / radiotherapy
  • Adenocarcinoma / therapy*
  • Adenocarcinoma / virology
  • Animals
  • Cell Line, Tumor
  • Combined Modality Therapy
  • Humans
  • Mice
  • Mice, Inbred BALB C
  • Oncolytic Virotherapy / methods*
  • Pancreatic Neoplasms / radiotherapy
  • Pancreatic Neoplasms / therapy*
  • Pancreatic Neoplasms / virology
  • Random Allocation
  • Vaccinia virus / physiology*
  • Xenograft Model Antitumor Assays