No differences in hippocampal volume between carriers and non-carriers of the ApoE ε4 and ε2 alleles in young healthy adolescents

Wasim Khan; Vincent Giampietro; Cedric Ginestet; Flavio Dell'Acqua; David Bouls; Steven Newhouse; Richard Dobson; Tobias Banaschewski; Gareth J Barker; Arun L W Bokde; Christian Büchel; Patricia Conrod; Herta Flor; Vincent Frouin; Hugh Garavan; Penny Gowland; Anreas Heinz; Bernd Ittermann; Hervé Lemaître; Frauke Nees; Tomas Paus; Zdenka Pausova; Marcella Rietschel; Michael N Smolka; Andreas Ströhle; Jean Gallinat; Eric Westman; Gunther Schumann; Simon Lovestone; Andrew Simmons; IMAGEN consortium

doi:10.3233/JAD-131841

No differences in hippocampal volume between carriers and non-carriers of the ApoE ε4 and ε2 alleles in young healthy adolescents

J Alzheimers Dis. 2014;40(1):37-43. doi: 10.3233/JAD-131841.

Authors

Wasim Khan¹, Vincent Giampietro², Cedric Ginestet³, Flavio Dell'Acqua¹, David Bouls¹, Steven Newhouse¹, Richard Dobson¹, Tobias Banaschewski⁴, Gareth J Barker², Arun L W Bokde⁵, Christian Büchel⁶, Patricia Conrod⁷, Herta Flor⁴, Vincent Frouin⁸, Hugh Garavan⁹, Penny Gowland¹⁰, Anreas Heinz¹¹, Bernd Ittermann¹², Hervé Lemaître¹³, Frauke Nees⁴, Tomas Paus¹⁴, Zdenka Pausova¹⁵, Marcella Rietschel⁴, Michael N Smolka¹⁶, Andreas Ströhle¹¹, Jean Gallinat¹¹, Eric Westman¹⁷, Gunther Schumann³, Simon Lovestone¹, Andrew Simmons¹; IMAGEN consortium

Affiliations

¹ King's College London, Institute of Psychiatry, London, UK NIHR Biomedical Research Centre for Mental Health, King's College London, London, UK NIHR Biomedical Research Unit for Dementia, King's College London, London, UK.
² King's College London, Institute of Psychiatry, London, UK.
³ King's College London, Institute of Psychiatry, London, UK NIHR Biomedical Research Centre for Mental Health, King's College London, London, UK.
⁴ Central Institute of Mental Health, Mannheim, Germany Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany.
⁵ Institute of Neuroscience and Discipline of Psychiatry, School of Medicine, Trinity College Dublin, Dublin, Ireland.
⁶ Universitaetsklinikum Hamburg Eppendorf, Hamburg, Germany.
⁷ King's College London, Institute of Psychiatry, London, UK Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité-Universitätsmedizin Berlin, Berlin, Germany.
⁸ Neurospin, Commissariat à l'Energie Atomique et aux Energies Alternatives, Paris, France.
⁹ Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland Departments of Psychiatry and Psychology, University of Vermont, Burlington, VT, USA.
¹⁰ School of Physics and Astronomy, University of Nottingham, Nottingham, UK.
¹¹ Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité-Universitätsmedizin Berlin, Berlin, Germany.
¹² Physikalisch-Technische Bundesanstalt (PTB), Braunschweig und Berlin, Berlin, Germany.
¹³ Institut National de la Santé et de la Recherche Médicale, INSERM CEA Unit 1000 "Imaging & Psychiatry", University Paris Sud, Orsay, and AP-HP Department of Adolescent Psychopathology and Medicine, Maison de Solenn, University Paris Descartes, Paris, France.
¹⁴ Rotman Research Institute, University of Toronto, Toronto, Canada School of Psychology, University of Nottingham, Nottingham, UK Montreal Neurological Institute, McGill University, Montreal, Canada.
¹⁵ The Hospital for Sick Children, University of Toronto, Toronto, Canada.
¹⁶ Neuroimaging Center, Department of Psychiatry and Psychotherapy, Technische Universität Dresden, Germany.
¹⁷ Karolinska Institute, Stockholm, Sweden.

PMID: 24326516
DOI: 10.3233/JAD-131841

Abstract

Alleles of the apolipoprotein E (ApoE) gene are known to modulate the genetic risk for developing late-onset Alzheimer's disease (AD) and have been associated with hippocampal volume differences in AD. However, the effect of these alleles on hippocampal volume in younger subjects has yet to be clearly established. Using a large cohort of more than 1,400 adolescents, this study found no hippocampal volume or hippocampal asymmetry differences between carriers and non-carriers of the ApoE ε4 or ε2 alleles, nor dose-dependent effects of either allele, suggesting that regionally specific effects of these polymorphisms may only become apparent in later life.

Keywords: Apolipoprotein E; hippocampal volume; magnetic resonance imaging; young healthy adolescents.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Apolipoprotein E4 / genetics*
Apolipoproteins E / genetics*
Cohort Studies
Female
Hippocampus / anatomy & histology*
Humans
Magnetic Resonance Imaging
Male

Substances

Apolipoprotein E4
Apolipoproteins E