A case of NUT midline carcinoma with no HPV infection, slight EWSR1 rearrangement and strong expression of EGFR

Tumori. 2013 Jul-Aug;99(4):e152-5. doi: 10.1177/030089161309900423.

Abstract

NUT midline carcinoma (NMC) is a rare neoplasm with a poor prognosis and involving mostly young patients. Here we describe a classic NMC with a BRD4-NUT fusion gene in a middle-aged woman. We also analyzed some biological features that could potentially influence its clinical behavior such as HPV infection, EWSR1 rearrangement, and the status of the EGFR gene.

Publication types

  • Case Reports

MeSH terms

  • Biomarkers, Tumor / genetics*
  • Calmodulin-Binding Proteins / genetics*
  • Carcinoma, Squamous Cell / genetics*
  • Carcinoma, Squamous Cell / metabolism
  • Carcinoma, Squamous Cell / secondary
  • Carcinoma, Squamous Cell / surgery*
  • ErbB Receptors / genetics*
  • Female
  • Gene Expression Regulation, Neoplastic
  • Gene Rearrangement*
  • Genes, erbB-1
  • Humans
  • Immunohistochemistry
  • In Situ Hybridization, Fluorescence
  • Laryngeal Neoplasms / genetics*
  • Laryngeal Neoplasms / metabolism
  • Laryngeal Neoplasms / pathology
  • Laryngeal Neoplasms / surgery*
  • Lymphatic Metastasis
  • Middle Aged
  • Nuclear Proteins / genetics*
  • Oncogene Proteins, Fusion / genetics*
  • RNA-Binding Protein EWS
  • RNA-Binding Proteins / genetics*

Substances

  • BRD4-NUT fusion oncogene protein, human
  • Biomarkers, Tumor
  • Calmodulin-Binding Proteins
  • EWSR1 protein, human
  • Nuclear Proteins
  • Oncogene Proteins, Fusion
  • RNA-Binding Protein EWS
  • RNA-Binding Proteins
  • EGFR protein, human
  • ErbB Receptors