Natural course of bleomycin-induced pneumonitis. A follow-up study

Am Rev Respir Dis. 1987 Jan;135(1):48-51. doi: 10.1164/arrd.1987.135.1.48.

Abstract

In this study, long-term pulmonary complications of bleomycin were evaluated in 8 patients with bleomycin-induced pneumonitis (BIP). The lung function parameters: VC, alveolar volume, transfer factor for carbon monoxide of the lungs, diffusing capacity of the alveolocapillary membrane, and pulmonary capillary blood volume were studied in all patients for as long as 2 yr after the development of BIP. Perfusion scans with 133Xe and 99mTc were performed in these patients 2 yr after BIP developed. We concluded that if a patient survives the acute event of BIP, the pulmonary symptoms and the changes in these lung function parameters are completely reversible.

MeSH terms

  • Adult
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Bleomycin / administration & dosage
  • Bleomycin / adverse effects*
  • Cisplatin / administration & dosage
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Pneumonia / chemically induced*
  • Pneumonia / diagnosis
  • Pneumonia / physiopathology
  • Respiratory Function Tests
  • Testicular Neoplasms / complications
  • Testicular Neoplasms / drug therapy
  • Time Factors
  • Vinblastine / administration & dosage

Substances

  • Bleomycin
  • Vinblastine
  • Cisplatin