Amorphous alumina nanowire array efficiently delivers Ac-DEVD-CHO to inhibit apoptosis of dendritic cells

Chem Commun (Camb). 2014 Feb 7;50(10):1234-7. doi: 10.1039/c3cc48088g.

Abstract

To create an effective well-ordered delivery platform still remains a challenge. Herein we fabricate vertically aligned alumina nanowire arrays via atomic layer deposition templated by carbon nanotubes. Using these arrays, a caspase-3/7 inhibitor was delivered into DC 2.4 cells and blocked apoptosis, as confirmed by fluorescence microscopy.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Aluminum Oxide
  • Animals
  • Apoptosis / drug effects*
  • CHO Cells
  • Caspase 3 / metabolism
  • Caspase 7 / metabolism
  • Caspase Inhibitors / pharmacology*
  • Cricetulus
  • Dendritic Cells / drug effects*
  • Drug Delivery Systems*
  • Microscopy, Electron, Transmission
  • Nanowires / chemistry*
  • Powders / chemistry

Substances

  • Caspase Inhibitors
  • Powders
  • Caspase 3
  • Caspase 7
  • Aluminum Oxide