Abstract
To create an effective well-ordered delivery platform still remains a challenge. Herein we fabricate vertically aligned alumina nanowire arrays via atomic layer deposition templated by carbon nanotubes. Using these arrays, a caspase-3/7 inhibitor was delivered into DC 2.4 cells and blocked apoptosis, as confirmed by fluorescence microscopy.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Aluminum Oxide
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Animals
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Apoptosis / drug effects*
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CHO Cells
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Caspase 3 / metabolism
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Caspase 7 / metabolism
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Caspase Inhibitors / pharmacology*
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Cricetulus
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Dendritic Cells / drug effects*
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Drug Delivery Systems*
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Microscopy, Electron, Transmission
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Nanowires / chemistry*
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Powders / chemistry
Substances
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Caspase Inhibitors
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Powders
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Caspase 3
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Caspase 7
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Aluminum Oxide