Utilizing combinatorial chemistry and rational design: peptidic tweezers with nanomolar affinity to DNA can be transformed into efficient vectors for gene delivery by addition of a lipophilic tail

Angew Chem Int Ed Engl. 2013 Dec 23;52(52):14016-20. doi: 10.1002/anie.201306929. Epub 2013 Nov 12.

Authors

Hannes Y Kuchelmeister¹, Sarah Karczewski, Aljona Gutschmidt, Shirley Knauer, Carsten Schmuck

Affiliation

¹ Institute for Organic Chemistry, University of Duisburg-Essen, 45117 Essen (Germany); Current address: Stanford University, Department of Chemistry, Stauffer I, Stanford, CA 94305 (USA).

PMID: 24353227
DOI: 10.1002/anie.201306929

No abstract available

Keywords: DNA binding; DNA transfection; DNA vectors; combinatorial chemistry; peptide tweezers.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Combinatorial Chemistry Techniques
DNA / genetics*
Gene Transfer Techniques
Genetic Vectors
Molecular Structure
Transfection

Substances

DNA