Factor VIII inhibitor epitopes and an enigma

Blood. 2013 Dec 19;122(26):4160-1. doi: 10.1182/blood-2013-10-531822.

Abstract

In this issue of Blood, Walter et al provide an x-ray crystallographic structure of the factor VIII C2 domain in complex with 2 antibodies that illuminates how inhibitory antibodies complicate hemophilia A therapy.

Publication types

  • Comment

MeSH terms

  • Antibodies / chemistry*
  • Epitopes / chemistry*
  • Factor VIII / chemistry*
  • Hemophilia A / blood*
  • Humans
  • Ternary Complex Factors / chemistry*

Substances

  • Antibodies
  • Epitopes
  • Ternary Complex Factors
  • Factor VIII