Abstract
The structure of a complex between influenza virus neuraminidase and an antibody displays features inconsistent with the inflexible 'lock and key' model of antigen-antibody binding. The structure of the antigen changes on binding, and that of the antibody may also change; the interaction therefore has some of the character of a handshake.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Antibodies, Viral / immunology
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Antigen-Antibody Complex*
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Antigens, Viral / immunology
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Epitopes / immunology
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Immunoglobulin Fab Fragments / immunology*
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Immunoglobulin Variable Region
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Macromolecular Substances
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Microscopy, Electron
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Neuraminidase / immunology*
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Orthomyxoviridae / enzymology*
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Orthomyxoviridae / immunology
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Protein Conformation
Substances
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Antibodies, Viral
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Antigen-Antibody Complex
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Antigens, Viral
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Epitopes
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Immunoglobulin Fab Fragments
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Immunoglobulin Variable Region
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Macromolecular Substances
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Neuraminidase