Immunoinflammatory response in critically ill patients: severe sepsis and/or trauma

Maja Surbatovic; Milic Veljovic; Jasna Jevdjic; Nada Popovic; Dragan Djordjevic; Sonja Radakovic

doi:10.1155/2013/362793

Immunoinflammatory response in critically ill patients: severe sepsis and/or trauma

Mediators Inflamm. 2013:2013:362793. doi: 10.1155/2013/362793. Epub 2013 Nov 24.

Authors

Maja Surbatovic¹, Milic Veljovic¹, Jasna Jevdjic², Nada Popovic³, Dragan Djordjevic¹, Sonja Radakovic⁴

Affiliations

¹ Clinic of Anesthesiology and Intensive Therapy, Military Medical Academy, Crnotravska 17, 11000 Belgrade, Serbia ; Faculty of Medicine of the Military Medical Academy, University of Defence, Crnotravska 17, 11000 Belgrade, Serbia.
² Clinical Center Kragujevac, Zmaj Jovina 30, 34000 Kragujevac, Serbia ; Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia.
³ Institute for Infectious and Tropical Diseases, Intensive Care Unit, Clinical Center of Serbia, Pasterova 2, 11000 Belgrade, Serbia ; School of Medicine, University of Belgrade, Dr. Subotica 8, 11000 Belgrade, Serbia.
⁴ Faculty of Medicine of the Military Medical Academy, University of Defence, Crnotravska 17, 11000 Belgrade, Serbia ; Sector of Preventive Medicine, Military Medical Academy, Crnotravska 17, 11000 Belgrade, Serbia.

Abstract

Immunoinflammatory response in critically ill patients is very complex. This review explores some of the new elements of immunoinflammatory response in severe sepsis, tumor necrosis factor-alpha in severe acute pancreatitis as a clinical example of immune response in sepsis, immune response in severe trauma with or without secondary sepsis, and genetic aspects of host immuno-inflammatory response to various insults in critically ill patients.

Publication types

Review

MeSH terms

Acute Disease
Critical Illness*
Humans
Lipopolysaccharide Receptors / genetics
Multiple Organ Failure / immunology
Pancreatitis / immunology
Polymorphism, Genetic
Sepsis / immunology*
Systemic Inflammatory Response Syndrome / etiology*
Systemic Inflammatory Response Syndrome / genetics
Tumor Necrosis Factor-alpha / genetics
Tumor Necrosis Factor-alpha / physiology
Wounds and Injuries / immunology*

Substances

Lipopolysaccharide Receptors
Tumor Necrosis Factor-alpha