Facile fabrication of polyanhydride/anesthetic nanoparticles with tunable release kinetics

Adv Healthc Mater. 2014 Jun;3(6):843-7. doi: 10.1002/adhm.201300521. Epub 2013 Dec 27.

Abstract

This work illustrates a two-step strategy for the fabrication of polymer/drug nanoparticles. Utilizing solvent/non-solvent precipitation and gaseous basification, composite nanoparticles with 0-100% drug loadings are fabricated. Drug release kinetics are dictated by nanoparticle composition allowing future tuning for therapeutic applications.

Keywords: anesthetics; nanoparticles; pain management; polymers.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Amides / chemistry
  • Amides / metabolism
  • Anesthetics / chemistry
  • Anesthetics / metabolism*
  • Humans
  • Kinetics
  • Nanoparticles / chemistry*
  • Nanoparticles / metabolism
  • Pain Management
  • Particle Size
  • Polyanhydrides / chemistry*
  • Ropivacaine
  • Solubility
  • Water / chemistry

Substances

  • Amides
  • Anesthetics
  • Polyanhydrides
  • Water
  • Ropivacaine