Effect of alpha-resorcylic acid-L-phenylalanine amide on collagen synthesis and matrix metalloproteinase expression in fibroblasts

Bioorg Med Chem Lett. 2014 Feb 1;24(3):742-5. doi: 10.1016/j.bmcl.2013.12.110. Epub 2014 Jan 3.

Abstract

Regulation of collagen synthesis and matrix metalloproteinases (MMPs) expression levels has been an important issue in medicinal, pharmaceutical and cosmetic industries. Herein, α-Resorcylic acid-phenylalanine amide (α-RA-F) was prepared and its biological activities were observed. We found that α-RA-F boosted collagen synthesis and reduced MMPs expression levels in human fibroblasts without cytotoxicity.

Keywords: Collagen synthesis; Resorcylic acid derivative; Suppression of MMPs expression.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Survival / drug effects
  • Cells, Cultured
  • Collagen / biosynthesis*
  • Fibroblasts / drug effects*
  • Fibroblasts / enzymology
  • Fibroblasts / metabolism
  • Gene Expression Regulation, Enzymologic / drug effects*
  • Humans
  • Hydroxybenzoates / chemistry
  • Hydroxybenzoates / pharmacology*
  • Matrix Metalloproteinases / drug effects
  • Matrix Metalloproteinases / genetics
  • Matrix Metalloproteinases / metabolism*
  • Models, Molecular
  • Phenylalanine / analogs & derivatives*
  • Phenylalanine / chemistry
  • Phenylalanine / pharmacology
  • RNA, Messenger / metabolism
  • Resorcinols / chemistry
  • Resorcinols / pharmacology*

Substances

  • Hydroxybenzoates
  • RNA, Messenger
  • Resorcinols
  • alpha-resorcylic acid
  • Phenylalanine
  • phenylalanine amide
  • Collagen
  • Matrix Metalloproteinases