A community cluster of influenza A(H1N1)pdm09 virus exhibiting cross-resistance to oseltamivir and peramivir in Japan, November to December 2013

Euro Surveill. 2014 Jan 9;19(1):20666. doi: 10.2807/1560-7917.es2014.19.1.20666.

Abstract

Six influenza A(H1N1)pdm09 viruses were detected in Sapporo, Japan, between November and December 2013. All six viruses possessed an H275Y substitution in the neuraminidase protein, which confers cross-resistance to oseltamivir and peramivir. No epidemiological link among the six cases could be identified; none of them had received neuraminidase inhibitors before specimen collection. The haemagglutinin and neuraminidase genes of the six viruses were closely related to one another, suggesting clonal spread of a single resistant virus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acids, Carbocyclic
  • Antiviral Agents / pharmacology*
  • Antiviral Agents / therapeutic use
  • Child
  • Child, Preschool
  • Cyclopentanes / pharmacology*
  • Cyclopentanes / therapeutic use
  • DNA, Viral
  • Drug Resistance, Viral
  • Female
  • Guanidines / pharmacology*
  • Guanidines / therapeutic use
  • Humans
  • Infant
  • Influenza A Virus, H1N1 Subtype / classification
  • Influenza A Virus, H1N1 Subtype / drug effects*
  • Influenza A Virus, H1N1 Subtype / genetics
  • Influenza A Virus, H1N1 Subtype / isolation & purification*
  • Influenza, Human / drug therapy*
  • Influenza, Human / virology
  • Japan / epidemiology
  • Male
  • Microbial Sensitivity Tests
  • Molecular Sequence Data
  • Mutation
  • Neuraminidase / genetics
  • Neuraminidase / therapeutic use
  • Oseltamivir / pharmacology*
  • Oseltamivir / therapeutic use
  • Phylogeny
  • Sequence Analysis, DNA
  • Treatment Outcome

Substances

  • Acids, Carbocyclic
  • Antiviral Agents
  • Cyclopentanes
  • DNA, Viral
  • Guanidines
  • Oseltamivir
  • Neuraminidase
  • peramivir