Two new pyrrolidine alkaloids, codonopsinol C and codonopiloside A, isolated from Codonopsis pilosula

Chem Pharm Bull (Tokyo). 2013;61(12):1315-7. doi: 10.1248/cpb.c13-00516.

Abstract

A new pyrrolidine alkaloid codonopsinol C (1), and pyrrolidine alkaloidal glycoside, codonopiloside A (2), were isolated from the roots of Codonopsis pilosula, along with four known pyrrolidine alkaloids, codonopsinol A (3), codonopsinol B (4), codonopyrrolidium B (5), and radicamine A (6). The structures of the new compounds were established by acid hydrolysis and spectroscopic methods. We describe those structures in this paper.

MeSH terms

  • Alkaloids / analysis*
  • Alkaloids / isolation & purification
  • Codonopsis / chemistry*
  • Glycosides / analysis*
  • Glycosides / isolation & purification
  • Hydrolysis
  • Plant Extracts / analysis*
  • Plant Extracts / isolation & purification
  • Plant Roots / chemistry
  • Pyrrolidines / analysis*
  • Pyrrolidines / isolation & purification

Substances

  • Alkaloids
  • Glycosides
  • Plant Extracts
  • Pyrrolidines