Abstract
A visible fluorescence switch of an eminent anti-carcinogen, ellipticine has been used to probe non-specific protein-DNA interaction. The unique pattern of protein-DNA complexation is depicted for the first time through field emission scanning electron microscopy (FE-SEM) images and spectroscopic techniques.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / pharmacology
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Cattle
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DNA / chemistry*
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DNA / metabolism
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Ellipticines / chemistry*
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Ellipticines / pharmacology
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Fluorescence Resonance Energy Transfer
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Protein Binding / drug effects
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Proteins / chemistry*
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Proteins / metabolism
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Serum Albumin / chemistry
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Serum Albumin / metabolism
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Serum Albumin, Bovine / chemistry
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Serum Albumin, Bovine / metabolism
Substances
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Antineoplastic Agents
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Ellipticines
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Proteins
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Serum Albumin
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ellipticine
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Serum Albumin, Bovine
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DNA
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calf thymus DNA