Intraoperative radiological margin assessment in breast-conserving surgery

Eur J Surg Oncol. 2014 Apr;40(4):449-53. doi: 10.1016/j.ejso.2014.01.002. Epub 2014 Jan 18.

Abstract

A prospective study was lead in order to analyze the accuracy of an X-ray device settled in the operating room for margin assessment, when performing breast-conserving surgery.

Patients and methods: One hundred and seventy patients were included. All lesions were visible on the preoperative mammograms. An intraoperative X-ray of the lumpectomy specimen was systematically performed for margins assessment. Final histological data were collected and the accuracy of intraoperative specimen radiography (IOSR) for margin assessment was analyzed.

Results: IOSR allowed an evaluation of margins status in 155 cases (91.2%). After final histological examination, the positive margins rate would have been 6.5% if margin assessment had relied only on IOSR.

Conclusion: Margin assessment with a two-dimensional X-ray device would have allowed the achievement of negative margins in 93.5% of the cases. Moreover, this procedure allows important time-saving and could have a substantial economical impact.

Keywords: Breast cancer; Faxitron; Intraoperative histological examination; Intraoperative specimen radiography; Mammograms; Margins status.

MeSH terms

  • Adult
  • Aged
  • Breast Neoplasms / diagnostic imaging*
  • Breast Neoplasms / pathology*
  • Breast Neoplasms / surgery
  • Carcinoma, Ductal, Breast / diagnostic imaging
  • Carcinoma, Ductal, Breast / pathology
  • Carcinoma, Ductal, Breast / surgery
  • Carcinoma, Lobular / diagnostic imaging
  • Carcinoma, Lobular / pathology
  • Carcinoma, Lobular / surgery
  • Female
  • Humans
  • Intraoperative Period
  • Mastectomy, Segmental*
  • Middle Aged
  • Neoplasm, Residual / diagnostic imaging*
  • Predictive Value of Tests
  • Prospective Studies
  • Radiography