Abstract
Hepatitis E virus (HEV) can cause chronic infections in immunocompromised hosts. Viral kinetics in plasma and stools are poorly understood, particularly during antiviral treatment. Prolonged faecal shedding may be a concern for transmission. We describe HEV kinetics in an immunocompromised patient with prolonged faecal shedding despite undetectable viraemia on ribavirin treatment.
Keywords:
Chronic infection; faecal shedding; hepatitis E virus; isolation; viral load.
© 2014 The Authors Clinical Microbiology and Infection © 2014 European Society of Clinical Microbiology and Infectious Diseases.
MeSH terms
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Alemtuzumab
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Antibodies, Monoclonal, Humanized / administration & dosage*
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Antiviral Agents / administration & dosage*
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Diarrhea / blood
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Diarrhea / drug therapy
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Diarrhea / immunology
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Diarrhea / virology*
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Drug Therapy, Combination
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Feces / virology*
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Female
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Hepatitis E / blood
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Hepatitis E / drug therapy*
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Hepatitis E / virology
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Hepatitis E virus / drug effects
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Hepatitis E virus / genetics
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Humans
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Immunocompromised Host*
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Middle Aged
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Prospective Studies
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Retrospective Studies
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Ribavirin / administration & dosage*
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Treatment Outcome
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Viral Load
Substances
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Antibodies, Monoclonal, Humanized
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Antiviral Agents
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Alemtuzumab
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Ribavirin