Expression of functional potassium channels from Shaker cDNA in Xenopus oocytes

Nature. 1988 Jan 14;331(6152):143-5. doi: 10.1038/331143a0.

Abstract

The Shaker gene of Drosophila melanogaster encodes a potassium-selective ion channel, the 'A' channel, or one of its subunits. A single Shaker messenger RNA species suffices to direct the synthesis of functional A channels in Xenopus oocytes. Physiological characteristics of the A currents induced by two different mRNA species are compared.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • DNA / genetics*
  • Drosophila melanogaster / genetics*
  • Injections
  • Ion Channels / metabolism*
  • Ion Channels / physiology
  • Kinetics
  • Mutation
  • Oocytes / metabolism*
  • Potassium / metabolism*
  • RNA, Messenger / pharmacology
  • Xenopus / metabolism*

Substances

  • Ion Channels
  • RNA, Messenger
  • DNA
  • Potassium