Efficacy of bepridil to prevent ventricular fibrillation in severe form of early repolarization syndrome

Goro Katsuumi; Wataru Shimizu; Hiroshi Watanabe; Takashi Noda; Akihiko Nogami; Kimie Ohkubo; Takeru Makiyama; Naofumi Takehara; Yuichiro Kawamura; Yukio Hosaka; Masahito Sato; Satoki Fukae; Masaomi Chinushi; Hirotaka Oda; Masaaki Okabe; Akinori Kimura; Koji Maemura; Ichiro Watanabe; Shiro Kamakura; Minoru Horie; Yoshifusa Aizawa; Naomasa Makita; Tohru Minamino

doi:10.1016/j.ijcard.2014.01.036

Efficacy of bepridil to prevent ventricular fibrillation in severe form of early repolarization syndrome

Int J Cardiol. 2014 Mar 15;172(2):519-22. doi: 10.1016/j.ijcard.2014.01.036. Epub 2014 Jan 23.

Authors

Goro Katsuumi¹, Wataru Shimizu², Hiroshi Watanabe³, Takashi Noda⁴, Akihiko Nogami⁵, Kimie Ohkubo⁶, Takeru Makiyama⁷, Naofumi Takehara⁸, Yuichiro Kawamura⁸, Yukio Hosaka⁹, Masahito Sato¹⁰, Satoki Fukae¹¹, Masaomi Chinushi¹, Hirotaka Oda⁹, Masaaki Okabe¹⁰, Akinori Kimura¹², Koji Maemura¹¹, Ichiro Watanabe⁶, Shiro Kamakura⁴, Minoru Horie¹³, Yoshifusa Aizawa¹, Naomasa Makita¹⁴, Tohru Minamino¹

Affiliations

¹ Department of Cardiovascular Biology and Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
² Division of Arrhythmia and Electrophysiology, Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan; Department of Cardiovascular Medicine, Nippon Medical School, Tokyo, Japan.
³ Department of Cardiovascular Biology and Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan. Electronic address: hiroshi7@med.niigata-u.ac.jp.
⁴ Division of Arrhythmia and Electrophysiology, Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan.
⁵ Division of Heart Rhythm Management, Yokohama Rosai Hospital, Yokohama, Japan.
⁶ Division of Cardiology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan.
⁷ Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
⁸ Department of Internal Medicine, Division of Cardiovascular Respiratory and Neurology, Asahikawa Medical University, Asahikawa, Japan.
⁹ Department of Cardiology, Niigata City General Hospital, Niigata, Japan.
¹⁰ Cardiovascular Center, Tachikawa General Hospital, Nagaoka, Japan.
¹¹ Departments of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
¹² Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, Japan.
¹³ Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Shiga, Japan.
¹⁴ Molecular Physiology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.

PMID: 24491875
DOI: 10.1016/j.ijcard.2014.01.036

No abstract available

Keywords: Arrhythmia; Bepridil; Electrocardiogram; Treatment; Ventricular fibrillation.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Anti-Arrhythmia Agents / pharmacology
Anti-Arrhythmia Agents / therapeutic use*
Bepridil / pharmacology
Bepridil / therapeutic use*
Follow-Up Studies
Heart Conduction System / drug effects*
Heart Conduction System / physiology
Humans
Male
Middle Aged
Severity of Illness Index*
Treatment Outcome
Ventricular Fibrillation / diagnosis*
Ventricular Fibrillation / drug therapy*
Ventricular Fibrillation / physiopathology

Substances

Anti-Arrhythmia Agents
Bepridil