Nephrotic sydrome developing in severe ovarian hyperstimulation syndrome

Int J Fertil Steril. 2014 Jan;7(4):345-8. Epub 2013 Dec 22.

Abstract

We report a case that developed nephrotic syndrome during hospitalization for severe ovarian hyperstimulation syndrome without history of acute renal failure. During hospi- talization, she developed persistent ascites and respiratory distress. The 24 hours urine protein analysis revealed significant proteinuria and renal biopsy showed global and seg- mental sclerosis in glomeruli, mesangial arteritis, proliferations in visceral epithelial cells (IgA nephropathy). To the best of our knowledge, such a complication will be presented for the first time in the literature.

Keywords: Ascites; In vitro Fertilization (IVF); Nephrotic Syndrome; Ovar- ian Stimulation; Ovarian Hyperstimulation Syndrome.