Wnt/β-catenin signaling inhibits the Shh pathway and impairs tumor growth in Shh-dependent medulloblastoma

Acta Neuropathol. 2014 Apr;127(4):605-7. doi: 10.1007/s00401-014-1258-2. Epub 2014 Feb 15.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cells, Cultured
  • Cerebellar Neoplasms / genetics
  • Cerebellar Neoplasms / metabolism*
  • Green Fluorescent Proteins / genetics
  • Green Fluorescent Proteins / metabolism
  • Hedgehog Proteins / genetics
  • Hedgehog Proteins / metabolism*
  • Humans
  • Ki-67 Antigen / metabolism
  • Lithium Chloride / pharmacology
  • Medulloblastoma / genetics
  • Medulloblastoma / metabolism*
  • Mice, Transgenic
  • Signal Transduction / drug effects
  • Signal Transduction / genetics
  • Signal Transduction / physiology*
  • Wnt Proteins / genetics
  • Wnt Proteins / metabolism*
  • beta Catenin / metabolism*

Substances

  • Hedgehog Proteins
  • Ki-67 Antigen
  • SHH protein, human
  • Wnt Proteins
  • beta Catenin
  • Green Fluorescent Proteins
  • Lithium Chloride