Iminosugar-based glycopolypeptides: glycosidase inhibition with bioinspired glycoprotein analogue micellar self-assemblies

Chem Commun (Camb). 2014 Mar 28;50(25):3350-2. doi: 10.1039/c3cc48190e.

Abstract

Biomimetic nanoparticles prepared by self-assembly of iminosugar-based glycopolypeptides evidenced remarkable multivalency properties when inhibiting α-mannosidase activity. This approach paves the way to obtain biologically active drug delivery systems having glycosidase inhibition potency.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 1-Deoxynojirimycin / analogs & derivatives
  • 1-Deoxynojirimycin / chemistry*
  • Drug Delivery Systems
  • Glycopeptides / chemistry*
  • Glycoproteins / chemistry
  • Glycoside Hydrolases / antagonists & inhibitors*
  • Ligands
  • Micelles
  • Nanoparticles / chemistry*
  • Peptides / chemistry*

Substances

  • Glycopeptides
  • Glycoproteins
  • Ligands
  • Micelles
  • Peptides
  • 1-Deoxynojirimycin
  • Glycoside Hydrolases