Are the medulloepithelioma, ependymoblastoma and embryonal tumor with multilayered rosettes the same entity?

Zh Vopr Neirokhir Im N N Burdenko. 2013;77(6):51-5.
[Article in English, Russian]

Abstract

Medulloepithelioma is a rare malignant tumor arising in cerebral hemispheres. Microscopically, medulloepithelioma is characterized by epithelial structures that mimic the embryonic neural tube. Immunohistochemical analysis revealed that tumor cells are immunopositive for LIN28A and fluorescence in situ hybridization showed an amplification of a miRNA cluster at 19q13.42. Presence of these both aberrations suggesting that medulloepithelioma, ependymoblastoma and embryonal tumor with multilayered rosettes are the same entity.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Brain Neoplasms* / classification
  • Brain Neoplasms* / genetics
  • Brain Neoplasms* / metabolism
  • Brain Neoplasms* / pathology
  • Brain Neoplasms* / surgery
  • Chromosomes, Human, Pair 19 / genetics*
  • Chromosomes, Human, Pair 19 / metabolism
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism*
  • Ependymoma* / classification
  • Ependymoma* / genetics
  • Ependymoma* / metabolism
  • Ependymoma* / pathology
  • Ependymoma* / surgery
  • Humans
  • Infant
  • Male
  • Neoplasm Proteins / genetics
  • Neoplasm Proteins / metabolism*
  • Neoplasms, Germ Cell and Embryonal* / classification
  • Neoplasms, Germ Cell and Embryonal* / genetics
  • Neoplasms, Germ Cell and Embryonal* / metabolism
  • Neoplasms, Germ Cell and Embryonal* / pathology
  • Neoplasms, Germ Cell and Embryonal* / surgery
  • Nerve Tissue Proteins / genetics
  • Nerve Tissue Proteins / metabolism*
  • Neuroectodermal Tumors, Primitive* / classification
  • Neuroectodermal Tumors, Primitive* / genetics
  • Neuroectodermal Tumors, Primitive* / metabolism
  • Neuroectodermal Tumors, Primitive* / pathology
  • Neuroectodermal Tumors, Primitive* / surgery
  • RNA-Binding Proteins

Substances

  • DNA-Binding Proteins
  • LIN28B protein, human
  • Neoplasm Proteins
  • Nerve Tissue Proteins
  • RNA-Binding Proteins