Too sweet for autophagy: hexokinase inhibition of mTORC1 activates autophagy

Mol Cell. 2014 Feb 20;53(4):517-8. doi: 10.1016/j.molcel.2014.02.009.

Abstract

In this issue, Roberts et al. (2014) describe how hexokinase and mTORC1 cooperate to sense disequilibrium between glucose uptake and utilization and direct the balance of anabolism and catabolism to ensure the appropriate use of cellular resources.

Publication types

  • Comment

MeSH terms

  • Animals
  • Autophagy*
  • Gene Expression Regulation, Enzymologic*
  • Glucose / metabolism*
  • Hexokinase / metabolism*
  • Mechanistic Target of Rapamycin Complex 1
  • Multiprotein Complexes / metabolism*
  • Myocytes, Cardiac / enzymology*
  • TOR Serine-Threonine Kinases / metabolism*

Substances

  • Multiprotein Complexes
  • Hexokinase
  • Mechanistic Target of Rapamycin Complex 1
  • TOR Serine-Threonine Kinases
  • Glucose