Anhedonia in obsessive-compulsive disorder: beyond comorbid depression

Psychiatry Res. 2014 May 15;216(2):223-9. doi: 10.1016/j.psychres.2014.02.002. Epub 2014 Feb 8.

Abstract

Obsessive-compulsive disorder (OCD) has been linked to reward dysfunctions, highlighting a possible role of anhedonia in OCD. Surprisingly, anhedonia in OCD has never been evaluated. Moreover, although nicotine typically has anti-anhedonic effects, anecdotal reports suggest low prevalence rates of smoking in OCD. To address these two phenomena, 113 individuals with OCD completed a battery of questionnaires assessing symptom severity, anhedonia, and smoking. 28.3% of the sample met criteria for clinically significant anhedonia, which correlated with Y-BOCS scores (r=0.44), even when controlling for depressive symptoms. 13.3% of the sample endorsed current smoking, a lower rate than seen in psychiatric disorders (40-90%) and the general adult population (19%). Results highlight high rates of anhedonia and yet reduced prevalence of smoking in OCD. In contrast to the known positive association between anhedonia and smoking, a negative association emerged. Future research is needed to address the unique interface between anhedonia and reward responsiveness in OCD. Potential clinical implications are discussed.

Keywords: Behavioral addiction; Nicotine; OCD; Pleasure; Reward; Smoking.

MeSH terms

  • Adolescent
  • Adult
  • Anhedonia*
  • Comorbidity
  • Depression* / epidemiology
  • Female
  • Humans
  • Male
  • Middle Aged
  • Nicotine / pharmacology
  • Obsessive-Compulsive Disorder / epidemiology
  • Obsessive-Compulsive Disorder / psychology*
  • Pleasure / drug effects
  • Prevalence
  • Reward
  • Smoking / epidemiology
  • Substance-Related Disorders / psychology
  • Surveys and Questionnaires
  • Young Adult

Substances

  • Nicotine