A targeted theranostic platinum(IV) prodrug containing a luminogen with aggregation-induced emission (AIE) characteristics for in situ monitoring of drug activation

Youyong Yuan; Yilong Chen; Ben Zhong Tang; Bin Liu

doi:10.1039/c3cc49516g

A targeted theranostic platinum(IV) prodrug containing a luminogen with aggregation-induced emission (AIE) characteristics for in situ monitoring of drug activation

Chem Commun (Camb). 2014 Apr 14;50(29):3868-70. doi: 10.1039/c3cc49516g. Epub 2014 Mar 4.

Authors

Youyong Yuan¹, Yilong Chen, Ben Zhong Tang, Bin Liu

Affiliation

¹ Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore117576. cheliub@nus.edu.sg.

PMID: 24589580
DOI: 10.1039/c3cc49516g

Abstract

A targeted theranostic platinum(IV) prodrug based on a luminogen with aggregation-induced emission (AIE) characteristics was developed for selective and real-time monitoring of drug activation in situ.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Line, Tumor
Cell Survival / drug effects
Coordination Complexes / chemistry
Coordination Complexes / metabolism
Coordination Complexes / toxicity
Fluorescent Dyes / chemistry*
Humans
MCF-7 Cells
Microscopy, Confocal
Oligopeptides / chemistry
Oligopeptides / metabolism
Platinum / chemistry*
Prodrugs / chemistry
Prodrugs / metabolism*
Prodrugs / toxicity
Pyridines / chemistry

Substances

Coordination Complexes
Fluorescent Dyes
Oligopeptides
Prodrugs
Pyridines
Platinum
arginyl-glycyl-aspartic acid
pyridine