Abstract
A novel palladium catalyzed approach to 3-arylindoles was developed from indoles and cyclohexanones. Various cyclohexanones acted as aryl sources via an alkylation and dehydrogenation sequence using molecular oxygen as the hydrogen acceptor. This method showed good regioselectivity and afforded 3-arylindoles as the sole products.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Catalysis
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Combinatorial Chemistry Techniques
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Cyclohexanones / chemistry*
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Heterocyclic Compounds, 3-Ring / chemical synthesis*
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Heterocyclic Compounds, 3-Ring / chemistry
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Indoles / chemical synthesis*
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Indoles / chemistry*
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Molecular Structure
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Palladium / chemistry*
Substances
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Cyclohexanones
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Heterocyclic Compounds, 3-Ring
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Indoles
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Palladium