The Psychosocial Care Center is seeing as a new strategy to address patients with mental disorders in that is has special features in everyday work that directly influence the practices developed by health professionals working in the area. To learn about the meaning of work for professionals working in a Psychosocial Care Center in the city of Belo Horizonte, Minas Gerais State, Brazil, a qualitative case study was conducted that included recorded interviews with 13 professionals from different categories. For data analysis, the technique of content analysis was used, and the results were as follows: professionals working in psychosocial care centers are satisfied with the new model of mental health care based on the anti-asylum proposal, and work fulfillment is due to the achievement of socially integrating individuals with mental disorders and helping them achieve autonomy.