Palladium-catalyzed oxidative C-H/C-H cross-coupling of benzothiazoles with thiophenes and thiazoles

Xuxing Chen; Xiaojing Huang; Qian He; Yuyuan Xie; Chunhao Yang

doi:10.1039/c4cc00362d

Palladium-catalyzed oxidative C-H/C-H cross-coupling of benzothiazoles with thiophenes and thiazoles

Chem Commun (Camb). 2014 Apr 18;50(30):3996-9. doi: 10.1039/c4cc00362d. Epub 2014 Mar 11.

Authors

Xuxing Chen¹, Xiaojing Huang, Qian He, Yuyuan Xie, Chunhao Yang

Affiliation

¹ State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, PR China. chyang@simm.ac.cn.

PMID: 24615183
DOI: 10.1039/c4cc00362d

Abstract

A concise palladium-catalyzed method for oxidative C-H/C-H cross-coupling between benzothiazoles and thiophenes/thiazoles has been developed. This CDC reaction is insensitive to air and moisture with high functional group tolerance.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Benzothiazoles / chemistry*
Catalysis
Molecular Structure
Oxidation-Reduction
Palladium / chemistry*
Thiazoles / chemistry*
Thiophenes / chemistry*

Substances

Benzothiazoles
Thiazoles
Thiophenes
Palladium