Abstract
The wheal and flare response to intradermal bradykinin was studied in man. The possibility that histamine and cyclooxygenase products are involved in the response to bradykinin was examined. Terfenadine given by mouth significantly inhibited the cutaneous response to histamine but the effect of bradykinin was unaltered. Similarly the cutaneous response to bradykinin was unchanged by aspirin.
Publication types
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Clinical Trial
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aspirin / pharmacology
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Benzhydryl Compounds / pharmacology
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Bradykinin*
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Histamine / pharmacology
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Histamine H1 Antagonists / pharmacology
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Histamine Release / drug effects*
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Humans
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Male
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Prostaglandin-Endoperoxide Synthases / metabolism*
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Skin Tests*
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Terfenadine
Substances
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Benzhydryl Compounds
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Histamine H1 Antagonists
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Terfenadine
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Histamine
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Prostaglandin-Endoperoxide Synthases
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Aspirin
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Bradykinin