Synthetic approaches to the 2012 new drugs

Abstract

New drugs introduced to the market every year represent a privileged structure for a particular biological target. These new chemical entities (NCEs) provide insights into molecular recognition and also serve as leads for designing future new drugs. This review covers the synthesis of twenty-six NCEs that were launched or approved worldwide in 2012 and two additional drugs which were launched at the end of 2011.

Keywords: Medicine; New chemical entities; New drug molecules; Synthesis; Therapeutic agents.