Loop de loop: viral RNA evades IFIT1 targeting

Justin A Roby; Brian D Clarke; Alexander A Khromykh

doi:10.1016/j.tim.2014.02.014

Loop de loop: viral RNA evades IFIT1 targeting

Trends Microbiol. 2014 Apr;22(4):171-3. doi: 10.1016/j.tim.2014.02.014. Epub 2014 Mar 13.

Authors

Justin A Roby¹, Brian D Clarke¹, Alexander A Khromykh²

Affiliations

¹ Australian Infectious Disease Research Centre, School of Chemistry and Molecular Biosciences, University of Queensland, St Luca, Brisbane, Queensland 4072, Australia.
² Australian Infectious Disease Research Centre, School of Chemistry and Molecular Biosciences, University of Queensland, St Luca, Brisbane, Queensland 4072, Australia. Electronic address: a.khromykh@uq.edu.au.

PMID: 24630528
DOI: 10.1016/j.tim.2014.02.014

Abstract

In a landmark finding published in Science, Hyde et al. have demonstrated that a hairpin RNA structure adjacent to the 5' cap of alphavirus genomic RNA confers the ability of these viruses to evade restriction by the interferon-induced host protein IFIT1.

Publication types

Comment

MeSH terms

Alphavirus / pathogenicity*
Alphavirus Infections / immunology*
Animals
Host-Pathogen Interactions / immunology*
RNA Caps / chemistry*
RNA Caps / immunology*
RNA, Viral / chemistry*
RNA, Viral / immunology*

Substances

RNA Caps
RNA, Viral