Nonhomologous end joining: a good solution for bad ends

Abstract

Double strand breaks pose unique problems for DNA repair, especially when broken ends possess complex structures that interfere with standard DNA transactions. Nonhomologous end joining can use multiple strategies to solve these problems. It further uses sophisticated means to ensure the strategy chosen provides the ideal balance of flexibility and accuracy.

Keywords: DNA damage; Double strand break repair; Nonhomologous end joining.