Long-lived reservoirs of HIV-1

Thomas D Zaikos; Kathleen L Collins

doi:10.1016/j.tim.2014.02.015

Long-lived reservoirs of HIV-1

Trends Microbiol. 2014 Apr;22(4):173-5. doi: 10.1016/j.tim.2014.02.015. Epub 2014 Mar 15.

Authors

Thomas D Zaikos¹, Kathleen L Collins²

Affiliations

¹ Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI, USA.
² Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI, USA; Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA. Electronic address: klcollins@umich.edu.

Abstract

HIV-1 persistence in long-lived cellular reservoirs remains a major barrier to a cure. In a recent Nature Medicine paper, Buzon et al. identify memory T cells with stem cell-like properties (TSCM) that harbor infectious provirus and that likely contribute to HIV-1 persistence.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

CD4-Positive T-Lymphocytes / virology*
Disease Reservoirs / virology*
HIV Infections / virology*
HIV-1 / genetics*
Humans
Lymphoid Progenitor Cells / cytology*
Phylogeny*
Virus Latency*

Grants and funding

R01 AI096962/AI/NIAID NIH HHS/United States