Atypical MRI features at early onset natalizumab-associated progressive multifocal leukoencephalopathy: a case report

J Neurol Sci. 2014 May 15;340(1-2):213-4. doi: 10.1016/j.jns.2014.02.037. Epub 2014 Mar 5.

Abstract

We report the case of a woman with natalizumab-treated Multiple Sclerosis (MS) that developed progressive multifocal leukoencephalopathy (PML) with atypical MRI features at early onset. This case shows that PML can have variable radiological patterns in natalizumab-treated MS patients thus expanding the possible MRI patterns at onset in these patients.

Keywords: MRI; Natalizumab; Progressive multifocal leukoencephalopathy.

Publication types

  • Case Reports

MeSH terms

  • Antibodies, Monoclonal, Humanized / therapeutic use*
  • Brain / drug effects
  • Brain / pathology
  • Female
  • Humans
  • Immunologic Factors / therapeutic use*
  • Leukoencephalopathy, Progressive Multifocal / drug therapy*
  • Leukoencephalopathy, Progressive Multifocal / pathology*
  • Magnetic Resonance Imaging
  • Middle Aged
  • Natalizumab

Substances

  • Antibodies, Monoclonal, Humanized
  • Immunologic Factors
  • Natalizumab