RNA identity crisis: hepatitis B walks the LINE

Yashar S Niknafs; Arul M Chinnaiyan

doi:10.1016/j.ccr.2014.02.011

RNA identity crisis: hepatitis B walks the LINE

Cancer Cell. 2014 Mar 17;25(3):259-60. doi: 10.1016/j.ccr.2014.02.011.

Authors

Yashar S Niknafs¹, Arul M Chinnaiyan²

Affiliations

¹ Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
² Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Howard Hughes Medical Institute, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Urology, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Electronic address: arul@med.umich.edu.

PMID: 24651004
DOI: 10.1016/j.ccr.2014.02.011

Abstract

Hepatitis B virus (HBV) integration into the host genome has been implicated in the causation of hepatocellular carcinoma (HCC). In this issue of Cancer Cell, Lau and colleagues report an HBV integration site recurrent in HCC that generates a chimeric transcript with oncogenic function as an RNA (but not protein) through stimulation of Wnt/β-catenin signaling.

Publication types

Comment

MeSH terms

Animals
Carcinoma, Hepatocellular / genetics*
DNA-Binding Proteins / genetics*
Humans
Liver Neoplasms / genetics*
Trans-Activators / genetics*
Viral Fusion Proteins / genetics*
Viral Regulatory and Accessory Proteins

Substances

DNA-Binding Proteins
Trans-Activators
Viral Fusion Proteins
Viral Regulatory and Accessory Proteins
hepatitis B virus X protein
L1Hs-encoded protein p40, human

Grants and funding

T32 GM007315/GM/NIGMS NIH HHS/United States