Whole transcriptome sequencing of a paediatric case of de novo acute myeloid leukaemia with del(5q) reveals RUNX1-USP42 and PRDM16-SKI fusion transcripts

Br J Haematol. 2014 Aug;166(3):449-52. doi: 10.1111/bjh.12855. Epub 2014 Mar 27.
No abstract available

Keywords: acute myeloid leukaemia; cancer genetics; childhood.

Publication types

  • Case Reports
  • Letter
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Child
  • Chromosome Deletion*
  • Chromosomes, Human, Pair 5*
  • Core Binding Factor Alpha 2 Subunit / genetics*
  • DNA-Binding Proteins / genetics*
  • Hematopoietic Stem Cell Transplantation
  • High-Throughput Nucleotide Sequencing
  • Humans
  • Leukemia, Myeloid, Acute / diagnosis
  • Leukemia, Myeloid, Acute / genetics*
  • Leukemia, Myeloid, Acute / therapy
  • Oncogene Proteins, Fusion / genetics*
  • Proto-Oncogene Proteins / genetics*
  • Thiolester Hydrolases / genetics*
  • Transcription Factors / genetics*
  • Transcriptome
  • Transplantation, Homologous
  • Treatment Outcome

Substances

  • Core Binding Factor Alpha 2 Subunit
  • DNA-Binding Proteins
  • Oncogene Proteins, Fusion
  • PRDM16 protein, human
  • Proto-Oncogene Proteins
  • Transcription Factors
  • USP42 protein, human
  • SKI protein, human
  • Thiolester Hydrolases