Multifunctional Fe5 C2 nanoparticles: a targeted theranostic platform for magnetic resonance imaging and photoacoustic tomography-guided photothermal therapy

Adv Mater. 2014 Jun 25;26(24):4114-20. doi: 10.1002/adma.201305811. Epub 2014 Mar 26.

Abstract

Fe5 C2 NPs exhibit a high contrast in magnetic resonance imaging (MRI), superior photoacoustic tomography improvements, and efficient photothermal therapy (PTT) due to their unique core/shell structure, with a magnetic core and carbon shell. By conjugating a new class of affinity proteins (ZHER2:342), they can target to tumor cells with low cytotoxicity, and kill them through laser irritation. It is also possible to ablate tumors under guidance by MRI and PTT without noticeable side effects.

Keywords: iron carbides; magnetic resonance imaging; multifunctional probes; photoacoustic tomography; photothermal therapy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Carbon Compounds, Inorganic / therapeutic use
  • Cell Line, Tumor
  • Iron Compounds / therapeutic use
  • Magnetic Resonance Imaging / methods*
  • Materials Testing
  • Metal Nanoparticles / therapeutic use*
  • Mice
  • Neoplasms, Experimental / pathology*
  • Neoplasms, Experimental / therapy*
  • Particle Size
  • Photoacoustic Techniques / methods*
  • Phototherapy / methods*
  • Treatment Outcome

Substances

  • Carbon Compounds, Inorganic
  • Iron Compounds
  • iron carbide