Psychiatric disorders: diagnosis to therapy

John H Krystal; Matthew W State

doi:10.1016/j.cell.2014.02.042

Psychiatric disorders: diagnosis to therapy

Cell. 2014 Mar 27;157(1):201-14. doi: 10.1016/j.cell.2014.02.042.

Authors

John H Krystal¹, Matthew W State²

Affiliations

¹ Departments of Psychiatry and Neurobiology, Yale University School of Medicine, New Haven, CT 06510, USA; VA National Center for PTSD, VA Connecticut Healthcare System, West Haven, CT 06516, USA. Electronic address: john.krystal@yale.edu.
² Department of Psychiatry and Langley Porter Psychiatric Institute, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: matthew.state@ucsf.edu.

Abstract

Recent findings in a range of scientific disciplines are challenging the conventional wisdom regarding the etiology, classification, and treatment of psychiatric disorders. This Review focuses on the current state of the psychiatric diagnostic nosology and recent progress in three areas: genomics, neuroimaging, and therapeutics development. The accelerating pace of novel and unexpected findings is transforming the understanding of mental illness and represents a hopeful sign that the approaches and models that have sustained the field for the past 40 years are yielding to a flood of new data and presaging the emergence of a new and more powerful scientific paradigm.

Publication types

Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Animals
Humans
Mental Disorders / classification
Mental Disorders / diagnosis*
Mental Disorders / genetics
Mental Disorders / therapy*
Neuroimaging
Neurosciences / methods*

Abstract

Publication types

MeSH terms

Grants and funding