Early infection of hip joint prosthesis by Clostridium difficile in an HIV-1 infected patient

L Brassinne; H Rodriguez-Villalobos; S Jonckheere; J E Dubuc; J C Yombi

doi:10.1016/j.anaerobe.2014.03.007

Early infection of hip joint prosthesis by Clostridium difficile in an HIV-1 infected patient

Anaerobe. 2014 Jun:27:96-9. doi: 10.1016/j.anaerobe.2014.03.007. Epub 2014 Apr 4.

Authors

L Brassinne¹, H Rodriguez-Villalobos², S Jonckheere³, J E Dubuc⁴, J C Yombi⁵

Affiliations

¹ Microbiology Department, Cliniques Universitaires Saint Luc, Université Catholique de Louvain, 10 Av Hippocrate, 1200 Brussels, Belgium. Electronic address: laeti.brassinne@skynet.be.
² Microbiology Department, Cliniques Universitaires Saint Luc, Université Catholique de Louvain, 10 Av Hippocrate, 1200 Brussels, Belgium. Electronic address: hector.rodriguez@uclouvain.be.
³ Internal Medicine and Infectious Diseases Department, Cliniques Universitaires Saint Luc, Université Catholique de Louvain, 10 Av Hippocrate, 1200 Brussels, Belgium. Electronic address: jonckheeresy@gmail.com.
⁴ Orthopaedic Department, Cliniques Universitaires Saint Luc, Université Catholique de Louvain, 10 Av Hippocrate, 1200 Brussels, Belgium. Electronic address: jean-emile.dubuc@uclouvain.be.
⁵ Internal Medicine and Infectious Diseases Department, Cliniques Universitaires Saint Luc, Université Catholique de Louvain, 10 Av Hippocrate, 1200 Brussels, Belgium. Electronic address: jean.yombi@uclouvain.be.

PMID: 24705255
DOI: 10.1016/j.anaerobe.2014.03.007

Abstract

Anaerobes are less frequently described as causative pathogen of prosthetic joint infection (PJI). We report the first case of early PJI after hip arthroplasty due to Clostridium difficile in a diabetic and HIV-1 infected patient with bacteremia. Our patient was successfully treated through surgical debridement and prosthesis retention combined with targeted antibiotic therapy.

Keywords: Anaerobes prosthetic infection; Clostridium difficile; HIV; Immunocompromised infection; Prosthetic joint infection.

Publication types

Case Reports

MeSH terms

Anti-Bacterial Agents / therapeutic use
Arthroplasty, Replacement, Hip / adverse effects
Bacteremia / diagnosis
Bacteremia / microbiology
Bacteremia / therapy
Clostridioides difficile / isolation & purification*
Clostridium Infections / diagnosis*
Clostridium Infections / microbiology
Clostridium Infections / therapy
Debridement
Diabetes Complications
HIV Infections / complications*
HIV-1 / isolation & purification
Hip Joint / microbiology*
Hip Joint / pathology*
Humans
Male
Middle Aged
Prosthesis-Related Infections / complications
Prosthesis-Related Infections / diagnosis*
Prosthesis-Related Infections / microbiology
Prosthesis-Related Infections / therapy

Substances

Anti-Bacterial Agents