Role of RyR2 phosphorylation in heart failure and arrhythmias: Controversies around ryanodine receptor phosphorylation in cardiac disease

Circ Res. 2014 Apr 11;114(8):1311-9; discussion 1319. doi: 10.1161/CIRCRESAHA.114.300568.

Abstract

Cardiac ryanodine receptor type 2 plays a key role in excitation-contraction coupling. The ryanodine receptor type 2 channel protein is modulated by various post-translational modifications, including phosphorylation by protein kinase A and Ca(2+)/calmodulin protein kinase II. Despite extensive research in this area, the functional effects of ryanodine receptor type 2 phosphorylation remain disputed. In particular, the potential involvement of increased ryanodine receptor type 2 phosphorylation in the pathogenesis of heart failure and arrhythmias remains a controversial area, which is discussed in this review article.

Keywords: atrial fibrillation; heart failure; phosphorylation; ryanodine receptor type 2.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Arrhythmias, Cardiac / metabolism*
  • Cyclic AMP-Dependent Protein Kinases / metabolism*
  • Heart Failure / metabolism*
  • Humans
  • Myocardial Contraction / physiology*
  • Ryanodine Receptor Calcium Release Channel / metabolism*

Substances

  • Ryanodine Receptor Calcium Release Channel
  • Cyclic AMP-Dependent Protein Kinases