Abstract
A novel series of substituted 2,4,5,6-tetrahydrocyclopenta[c]pyrazoles were investigated as N-type calcium channel blockers (Cav2.2 channels), a chronic pain target. One compound was active in vivo in the rat CFA pain model.
Keywords:
2,4,5,6-Tetrahydrocyclopenta[c]pyrazoles; Ca(v)2.2 blockers; N-type calcium channel; Pain; Rat CFA model.
Copyright © 2014 Elsevier Ltd. All rights reserved.
MeSH terms
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Analgesics / chemistry*
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Analgesics / metabolism
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Analgesics / pharmacokinetics
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Analgesics / pharmacology*
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Animals
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Calcium Channel Blockers / chemistry*
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Calcium Channel Blockers / metabolism
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Calcium Channel Blockers / pharmacokinetics
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Calcium Channel Blockers / pharmacology*
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Calcium Channels, N-Type / metabolism*
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Microsomes, Liver / metabolism
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Pain / drug therapy
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Pyrazoles / chemistry*
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Pyrazoles / metabolism
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Pyrazoles / pharmacokinetics
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Pyrazoles / pharmacology*
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Rats
Substances
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Analgesics
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Cacna1b protein, rat
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Calcium Channel Blockers
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Calcium Channels, N-Type
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Pyrazoles