Signaling regulations of neuronal regenerative ability

Yi Lu; Stéphane Belin; Zhigang He

doi:10.1016/j.conb.2014.03.007

Signaling regulations of neuronal regenerative ability

Curr Opin Neurobiol. 2014 Aug:27:135-42. doi: 10.1016/j.conb.2014.03.007. Epub 2014 Apr 12.

Authors

Yi Lu¹, Stéphane Belin², Zhigang He³

Affiliations

¹ Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; F.M. Kirby Neurobiology Center, Boston Children's Hospital, and Department of Neurology, Harvard Medical School, Boston, MA 02115, USA.
² F.M. Kirby Neurobiology Center, Boston Children's Hospital, and Department of Neurology, Harvard Medical School, Boston, MA 02115, USA.
³ F.M. Kirby Neurobiology Center, Boston Children's Hospital, and Department of Neurology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: zhigang.he@childrens.harvard.edu.

Abstract

Different from physiological axon growth during development, a major limiting factor for successful axon regeneration is the poor intrinsic regenerative capacity in mature neurons in the adult mammalian central nervous system (CNS). Recent studies identified several molecular pathways, including PTEN/mTOR, Jak/STAT, DLK/JNK, providing important probes in investigating the mechanisms by which the regenerative ability is regulated. This review will summarize these recent findings and speculate their implications.

Publication types

Review

MeSH terms

Animals
Axons / physiology*
Central Nervous System / cytology*
Central Nervous System / physiology
Humans
Janus Kinases / metabolism
MAP Kinase Kinase 4
Nerve Regeneration / physiology*
Neurons / cytology*
Neurons / physiology
PTEN Phosphohydrolase / metabolism
Signal Transduction / physiology*

Substances

Janus Kinases
MAP Kinase Kinase 4
PTEN Phosphohydrolase

Abstract

Publication types

MeSH terms

Substances

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