Abstract
Prior to a chimpanzee adenovirus-based (ChAd63) malarial vaccine trial, sera were collected to assess ChAd63-specific neutralizing antibody titers in Banfora (Burkina Faso). The low neutralizing antibody titers reported in both adults and children (median titers, 139.1 and 35.0, respectively) are encouraging for the potential use of ChAd63 as a malarial vaccine vector.
Copyright © 2014, American Society for Microbiology. All Rights Reserved.
MeSH terms
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Adenoviruses, Simian / classification
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Adenoviruses, Simian / immunology*
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Adolescent
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Adult
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Animals
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Antibodies, Neutralizing / blood*
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Antibodies, Neutralizing / immunology
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Antibodies, Viral / blood*
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Antibodies, Viral / immunology
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Burkina Faso
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Child
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Child, Preschool
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Cohort Studies
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Humans
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Infant
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Malaria Vaccines / immunology*
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Malaria, Falciparum / immunology*
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Malaria, Falciparum / prevention & control
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Middle Aged
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Pan troglodytes
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Young Adult
Substances
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Antibodies, Neutralizing
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Antibodies, Viral
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Malaria Vaccines