Hydrotrifluoromethylthiolation of α-diazo esters--synthesis of α-SCF3 substituted esters

Chem Commun (Camb). 2014 Jun 25;50(50):6617-9. doi: 10.1039/c4cc02060j.

Abstract

A practical protocol for hydrotrifluoromethylthiolation of diazo compounds has been developed. A range of diazo compounds in combination with a nucleophilic SCF3 source provided access to valuable trifluoromethylthiolated compounds. Furthermore, a methodology for the first double trifluoromethylthiolation was developed.