Genomics in primary care practice

Kathryn Teng; Louise S Acheson

doi:10.1016/j.pop.2014.02.012

Genomics in primary care practice

Prim Care. 2014 Jun;41(2):421-35. doi: 10.1016/j.pop.2014.02.012. Epub 2014 Mar 26.

Authors

Kathryn Teng¹, Louise S Acheson²

Affiliations

¹ Internal Medicine, Center for Personalized Healthcare (Cleveland Clinic), 9500 Euclid Avenue, NE5-203, Cleveland, OH 44195, USA. Electronic address: tengk@ccf.org.
² Departments of Family Medicine, Oncology, and Reproductive Biology, University Hospitals Case Medical Center, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106-5036, USA.

PMID: 24830615
DOI: 10.1016/j.pop.2014.02.012

Abstract

This article discusses the clinical utility of genomic information for personalized preventive care of a healthy adult. Family health history is currently the most applicable genomic predictor for common, multifactorial diseases, and can also show patterns that suggest an inherited high susceptibility to a particular form of cancer or other disease. Both bloodline ancestry and shared environmental factors are important predictors for many disease states. DNA and family history analyses give information that is probabilistic, not deterministic. Therefore, family history can highlight behavioral, social, or cultural risk factors that can be modified to prevent diseases.

Keywords: Ancestry; Family health history; Genomic; Preventive care; Primary care; Value.

Publication types

Review

MeSH terms

Ethnicity / genetics
Family Health
Genetic Counseling
Genetic Predisposition to Disease / genetics*
Genetic Testing / methods*
Humans
Primary Health Care / organization & administration*
Racial Groups / genetics
Risk Assessment
Risk Factors