Attentional alterations in alcohol dependence are underpinned by specific executive control deficits

Alcohol Clin Exp Res. 2014 Jul;38(7):2105-12. doi: 10.1111/acer.12444. Epub 2014 May 20.

Abstract

Background: Attentional biases and deficits play a central role in the development and maintenance of alcohol dependence, but the underlying attentional processes accounting for these deficits have been very little explored. Importantly, the differential alterations across the 3 attentional networks (alerting, orienting, and executive control) remain unclear in this pathology.

Methods: Thirty recently detoxified alcohol-dependent individuals and 30 paired controls completed the Attention Network Test, which allow exploring the attentional alterations specifically related to the 3 attentional networks.

Results: Alcohol-dependent individuals presented globally delayed reaction times compared to controls. More centrally, they showed a differential deficit across attention networks, with a preserved performance for alerting and orienting networks but impaired executive control (p < 0.001). This deficit was not related to psychopathological comorbidities but was positively correlated with the duration of alcohol-dependence habits, the number of previous detoxification treatments and the mean alcohol consumption before detoxification.

Conclusions: These results suggest that attentional alterations in alcohol dependence are centrally due to a specific alteration of executive control. Intervention programs focusing on executive components of attention should be promoted, and these results support the frontal lobe hypothesis.

Keywords: Alcohol Dependence; Attention Network Test; Attentional Networks; Executive Control.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alcoholism / complications
  • Alcoholism / psychology*
  • Attention / drug effects*
  • Case-Control Studies
  • Cognition Disorders / complications
  • Cognition Disorders / psychology*
  • Executive Function / drug effects*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Neuropsychological Tests
  • Reaction Time