Die another day: a painless path to longevity

Cell. 2014 May 22;157(5):1004-6. doi: 10.1016/j.cell.2014.05.013.

Abstract

Riera et al. identify a neuroendocrine circuit that controls longevity and the age-dependent onset of metabolic decline via the pain-transducing channel TRPV1. Thus, pharmacological inhibition of TRPV1 may provide a new approach to treat not only metabolic disorders but also a broader range of age-related pathologies.

Publication types

  • Comment

MeSH terms

  • Animals
  • Female
  • Longevity*
  • Male
  • Signal Transduction*
  • TRPV Cation Channels / metabolism*

Substances

  • TRPV Cation Channels
  • TRPV1 protein, mouse