Background: Plasma gelsolin is a circulating actin-binding protein that has a protective role against tissue injuries. Our aim was to compare the baseline levels of gelsolin in premature infants with neonatal outcomes.
Methods: A total of 32 preterm neonates born at 23-32 weeks of gestation were enrolled in the study.
Results: Plasma gelsolin levels at 72 h were significantly lower in patients with respiratory distress syndrome, in patients who were administered surfactant therapy and in patients who developed sepsis (P < 0.05). Plasma gelsolin levels at 28 days were significantly lower in patients who developed bronchopulmonary dysplasia and retinopathy of prematurity (P < 0.05).
Conclusions: Low plasma gelsolin levels in the first postnatal month may be associated with poor outcomes in premature infants.
Keywords: gelsolin; neonatal outcomes; prematurity.
© 2014 Japan Pediatric Society.